High-fat diet caused widespread epigenomic differences on hepatic methylome in rat.

@article{Zhang2015HighfatDC,
  title={High-fat diet caused widespread epigenomic differences on hepatic methylome in rat.},
  author={Yukun Zhang and Huan Wang and Dan Zhou and Laura Moody and St{\'e}phane Lezmi and Hong Chen and Yuan-Xiang Pan},
  journal={Physiological genomics},
  year={2015},
  volume={47 10},
  pages={514-23}
}
A high-fat (HF) diet is associated with progression of liver diseases. To illustrate genome-wide landscape of DNA methylation in liver of rats fed either a control or HF diet, two enrichment-based methods, namely methyl-DNA immunoprecipitation assay with high-throughput sequencing (MeDIP-seq) and methylation-sensitive restriction enzyme sequencing (MRE-seq), were performed in our study. Rats fed with the HF diet exhibited an increased body weight and liver fat accumulation compared with that of… CONTINUE READING
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