High extracellular glycine does not potentiate N-methyl-D-aspartate-evoked depolarization in vivo.

@article{Obrenovitch1997HighEG,
  title={High extracellular glycine does not potentiate N-methyl-D-aspartate-evoked depolarization in vivo.},
  author={Tihomir P. Obrenovitch and Aidan M. Hardy and Jutta Urenjak},
  journal={Brain research},
  year={1997},
  volume={746 1-2},
  pages={190-4}
}
As N-methyl-D-aspartate receptor (NMDA) ionophore complexes have a distinct positive, allosteric regulatory site for glycine, it has been proposed that elevated extracellular glycine during or after cerebral ischaemia may induce excessive NMDA/glutamate receptor activation and, thereby, excitotoxicity. To test this hypothesis, we have perfused increasing concentrations of glycine, either alone or with co-application of NMDA, through a microdialysis probe implanted in the striatum of halothane… CONTINUE READING

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