High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

@article{Uguccioni1997HighEO,
  title={High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.},
  author={Mariagrazia Uguccioni and Charles R Mackay and B Ochensberger and Pius Loetscher and S Rhis and Gregory J Larosa and P. R. Sheshagiri Rao and Paul D. Ponath and Marco Baggiolini and Clemens Andreas Dahinden},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 5},
  pages={1137-43}
}
Eosinophil leukocytes express high numbers of the chemokine receptor CCR3 which binds eotaxin, monocyte chemotactic protein (MCP)-4, and some other CC chemokines. In this paper we show that CCR3 is also highly expressed on human blood basophils, as indicated by Northern blotting and flow cytometry, and mediates mainly chemotaxis. Eotaxin and MCP-4 elicited basophil migration in vitro with similar efficacy as regulated upon activation normal T cells expressed and secreted (RANTES) and MCP-3… CONTINUE READING
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Structure and functional expression of the human macrophage inflammatory protein 1a/RANTES receptor

  • Gao, J.-L, +5 authors P. M. Murphy
  • J. Exp. Med
  • 1993
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