High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats.

@article{Li2011HighEO,
  title={High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats.},
  author={Dongmin Li and Xuan Wang and Wuchao Ren and Juan Ren and Xi Lan and Feimiao Wang and Hongmin Li and Fujun Zhang and Yan Han and Tianbao Song and Rikard Holmdahl and Shemin Lu},
  journal={Molecular and cellular endocrinology},
  year={2011},
  volume={344 1-2},
  pages={69-80}
}
In the previous experiment, we found that there was a different response between E3 rats and DA.1U rats to high-fat-diet-induced metabolic syndrome (HFD-MetS). The aim of this study was to explore the cause and molecular mechanism of the genetic difference in susceptibility to metabolic syndrome in E3 rats as compared with DA.1U rats. Firstly, a 12-week HFD-MetS model in E3 and DA.1U rats was carried out and assessed. Then, the expression of key insulin signaling molecules, metabolic nuclear… CONTINUE READING

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