High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia

@article{Heintel2005HighEO,
  title={High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia},
  author={Daniel Heintel and Dirk L. Kienle and Medhat Shehata and Alexander Kr{\"o}ber and Elisabeth Kroemer and Ilse Schwarzinger and Dieter Mitteregger and Trang Le and Andreas Gleiss and Christine Mannhalter and Andreas Chott and Josef D. Schwarzmeier and Christa Fonatsch and Alexander Gaiger and Hartmut D{\"o}hner and Stephan Stilgenbauer and Ulrich J{\"a}ger},
  journal={Leukemia},
  year={2005},
  volume={19},
  pages={1216-1223}
}
We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. Expression of LPL mRNA as well as protein was highly restricted to leukemic B cells. The intensity of intracellular immunoreactivity of LPL was higher in samples of patients with unmutated immunoglobulin heavy-chain variable region genes (IGVH) compared to those with mutated IGVH genes. LPL mRNA levels in peripheral blood mononuclear cells… 

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