High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.

@article{Wislez2006HighEO,
  title={High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.},
  author={Marie Wislez and Nobukazu Fujimoto and Julie G. Izzo and Amy E. Hanna and Megan C. Jacobsen and Robert R. Langley and Hongli Tang and Marie D. Burdick and Mitsuo Sato and John D. Minna and Li Mao and Ignacio I. Wistuba and Robert M. Strieter and Jonathan M. Kurie},
  journal={Cancer research},
  year={2006},
  volume={66 8},
  pages={
          4198-207
        }
}
CXCL8, a ligand for the chemokine receptor CXCR2, was recently reported to be a transcriptional target of Ras signaling, but its role in Ras-induced tumorigenesis has not been fully defined. Here, we investigated the role of KC and MIP-2, the murine homologues of CXCL8, in Kras(LA1) mice, which develop lung adenocarcinoma owing to somatic activation of the KRAS oncogene. We first investigated biological evidence of CXCR2 ligands in Kras(LA1) mice. Malignant progression of normal alveolar… CONTINUE READING
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