High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.

Abstract

Tumor cells maintain an especially high glycolytic rate to supply the anabolic precursors essential for de novo nucleotide synthesis. We recently cloned an inducible isozyme of 6-phosphofructo-2 kinase (iPFK-2) that bears an oncogene-like regulatory element in its mRNA and functions to produce fructose-2,6-bisphosphate, which is a powerful allosteric… (More)

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@article{Atsumi2002HighEO, title={High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.}, author={Toshiya Atsumi and Jason A Chesney and Christine N Metz and Lin Leng and Seamas Donnelly and Zenji Makita and Robert A Mitchell and Richard J. Bucala}, journal={Cancer research}, year={2002}, volume={62 20}, pages={5881-7} }