High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences.

@article{Fabry1992HighEO,
  title={High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences.},
  author={Mary E. Fabry and Ronald L. Nagel and Agathe Pachnis and Sandra M. Suzuka and Frank D. Costantini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 24},
  pages={
          12150-4
        }
}
A line of transgenic mice (alpha H beta S-11; where alpha H is human alpha-globin) was created in which the human beta S and human alpha 2 globin genes, each linked to the beta-globin locus control region, were cointegrated into the mouse genome. On a normal genetic background, the transgenic mice produced 36% human beta S-globin chains with an alpha H/beta S ratio of 1.3. Higher levels of beta S were achieved by breeding the transgenic mice with mutant mice carrying a mouse beta major-globin… CONTINUE READING
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