High expression of doublecortin and KIAA0369 protein in fetal brain suggests their specific role in neuronal migration.

@article{Mizuguchi1999HighEO,
  title={High expression of doublecortin and KIAA0369 protein in fetal brain suggests their specific role in neuronal migration.},
  author={Masashi Mizuguchi and Junwen Qin and Marina Yamada and Kazuhiko Ikeda and Sachio Takashima},
  journal={The American journal of pathology},
  year={1999},
  volume={155 5},
  pages={1713-21}
}
The X-linked subcortical laminar heterotopia and lissencephaly syndrome is a disorder of neuronal migration caused by a mutation in XLIS, a recently cloned gene on chromosome Xq22.3-q23. The predicted protein product for XLIS, doublecortin (DC), shows high homology to a putative calcium calmodulin-dependent kinase, KIAA0369 protein (KI). Here we identified DC and KI in the brains of human and rat fetuses by immunochemical and immunohistochemical means. In this study, Western blotting… CONTINUE READING
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