High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody.

@article{Vaskova2011HighEO,
  title={High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody.},
  author={Martina Vaskova and Martin Kov{\'a}{\vc} and Petra Voln{\'a} and Pavla Angelisov{\'a} and Ester Mejstrikova and Jan Zuna and Tomas Brdicka and Ondrej Hrusak},
  journal={Leukemia research},
  year={2011},
  volume={35 8},
  pages={
          1111-3
        }
}
The expression of drebrin, a cytoskeletal protein newly estimated by expression profiling to correlate with the genotype and prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), was examined by independent methods. After demonstrating its higher expression in TEL/AML1(pos) BCP-ALL by quantitative reverse transcriptase polymerase chain reaction, we developed an anti-drebrin monoclonal antibody (mAb). In a cohort of 86 children with BCP-ALL, we found increased expression of… CONTINUE READING

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