High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas

@article{Colin2009HighEO,
  title={High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas},
  author={Carole Colin and Brigitte Voutsinos-Porche and Isabelle Nanni and Fr{\'e}d{\'e}ric Fina and Philippe M{\'e}tellus and Dominique Intagliata and Nathalie Baeza and Corinne Bouvier and Christine J Delfino and Anderson Dieudonn{\'e} Loundou and Olivier Louis Chinot and T. Sing Lah and Janko Kos and Primrose Martin and L’houcine Ouafik and Dominique F. Figarella-Branger},
  journal={Acta Neuropathologica},
  year={2009},
  volume={118},
  pages={745-754}
}
In contrast to pilocytic astrocytomas (WHO grade I gliomas) that are circumscribed and cured by surgical resection, invasion is a hallmark of grades II–IV gliomas. Proteases play a major role in the invasion process and correlations between glioma grading, survival and protease expression have been demonstrated. In this study, we have chosen to study using different technical approaches (Q-RT-PCR, in situ hybridization and immunohistochemistry) the expression of five molecules involved in… CONTINUE READING
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a tumour deriving from radial glia cells with a specific gene signature

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