High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia

@article{Heintel2004HighEO,
  title={High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia},
  author={Daniel Heintel and Elisabeth Kroemer and Diego Kienle and Ilse Schwarzinger and Andreas Gleiss and Josef Schwarzmeier and Rodrig Marculescu and Trang Ngoc Le and Ch Mannhalter and Anat Gaiger and S. Stilgenbauer and Hartmut D{\"o}hner and Christa Fonatsch and Ulrich Jäger and the German Cll Study Group},
  journal={Leukemia},
  year={2004},
  volume={18},
  pages={756-762}
}
Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation of B-cells. We investigated the expression of AID mRNA by real-time polymerase chain reaction (PCR) in peripheral blood mononuclear cells of 80 patients with B-CLL. AID expression was detected in 45 of 80 patients (56%) at various levels, but was undetectable in 35 patients (44%). AID PCR positivity was associated with unmutated IGVH gene status (22 of 25 patients; P=0.002) and unfavourable cytogenetics (18 of 23… CONTINUE READING

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