High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia.

@article{McCarthy2003HighEO,
  title={High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia.},
  author={Helen McCarthy and William G Wierda and Lynn L. Barron and Candy C. Cromwell and Jing Wang and Kevin R. Coombes and Roberto Rangel and Kojo S. J. Elenitoba-Johnson and Michael J Keating and Lynne V. Abruzzo},
  journal={Blood},
  year={2003},
  volume={101 12},
  pages={4903-8}
}
In chronic lymphocytic leukemia (CLL), analysis of immunoglobulin heavy chain variable regions for somatic hypermutation identifies 2 prognostic subsets, mutated and unmutated. Investigators have postulated that unmutated and mutated CLL arises from malignant transformation of pre- and post-germinal center (GC) B cells, respectively. Alternatively, unmutated cases may arise from B cells stimulated by T-cell-independent antigens or from GC B cells with inactive somatic hypermutation. Activation… CONTINUE READING

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Chronic lymphocytic leukemia (CLL) patients with unmutated Ig VH genes express high levels of activation-induced cytidine deaminase (AICD) mRNA and splice variants [abstract

H McCarthy, W Wierda, L Barron
Blood. 2002;100: • 2003

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