High expression of YB-1 gene in erythroid cells in patients with refractory anemia.

@article{Yokoyama2003HighEO,
  title={High expression of YB-1 gene in erythroid cells in patients with refractory anemia.},
  author={Hisayuki Yokoyama and Hideo Harigae and Shinichiro Takahashi and Junichi Kameoka and Koichi Miyamura and Kenichi Ishizawa and Mitsuo Kaku and Takeshi Sasaki},
  journal={International journal of hematology},
  year={2003},
  volume={78 3},
  pages={213-8}
}
It has been shown that aberrant expression of a transcription factor, GATA-1, leads to maturation arrest and transformation of erythroid cells. We previously reported that a multifunctional protein, YB-1, was expressed strongly in the spleen of a GATA-1 mutant mouse, which was filled with transformed erythroblasts. This finding suggested that YB-1 has roles in erythropoiesis. In this study, we examined in vivo expression of YB-1 messenger RNA (mRNA) in bone marrow erythroid cells and erythroid… CONTINUE READING