High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions.

@article{Ichinoe2011HighEO,
  title={High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions.},
  author={Masaaki Ichinoe and Tetuo Mikami and Tsutomu Yoshida and Ikuyo Igawa and Tomoko Tsuruta and Norihiro Nakada and Naohiko Anzai and Yoshiyuki Suzuki and Hitoshi Endou and Isao Okayasu},
  journal={Pathology international},
  year={2011},
  volume={61 5},
  pages={281-9}
}
Amino acid transporters are essential for maintenance and proliferation of both normal and transformed cells. In the present study, L-type amino-acid transporter 1 (LAT1) immunoreactive expression was investigated in gastric carcinomas, in comparison with gastric adenomas and non-neoplastic lesions, using our recently developed novel monoclonal antibody. In a total of 87 cases of advanced gastric cancer, high LAT1 expression was observed in carcinoma cells, predominantly at plasma membranes… CONTINUE READING
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