High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism.

@article{Nakagome2011HighEO,
  title={High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism.},
  author={Kazuyuki Nakagome and Mitsuru Imamura and Kimito Kawahata and Hiroaki Harada and Katsuhide Okunishi and Taku Matsumoto and Oh Sasaki and Ryouichi Tanaka and Mitsunobu R Kano and He Chang and Haruo Hanawa and Jun-Ichi Miyazaki and Kazuhiko Yamamoto and Makoto Dohi},
  journal={Journal of immunology},
  year={2011},
  volume={187 10},
  pages={5077-89}
}
Allergic inflammation in the airway is generally considered a Th2-type immune response. However, Th17-type immune responses also play important roles in this process, especially in the pathogenesis of severe asthma. IL-22 is a Th17-type cytokine and thus might play roles in the development of allergic airway inflammation. There is increasing evidence that IL-22 can act as a proinflammatory or anti-inflammatory cytokine depending on the inflammatory context. However, its role in Ag-induced… CONTINUE READING

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