High expression of CXCR4 and stem cell markers in a monocrotaline and chronic hypoxia-induced rat model of pulmonary arterial hypertension

@inproceedings{Zhang2018HighEO,
  title={High expression of CXCR4 and stem cell markers in a monocrotaline and chronic hypoxia-induced rat model of pulmonary arterial hypertension},
  author={Tingting Zhang and Nanako Kawaguchi and Emiko Hayama and Yoshiyuki Furutani and Toshio Nakanishi},
  booktitle={Experimental and therapeutic medicine},
  year={2018}
}
Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome. C-X-C chemokine receptor type 4 (CXCR4) is known to serve a key role in recruiting mesenchymal stem cells (MSCs) from the bone marrow. In the present study, a rat model of PAH induced by 5 weeks of chronic hypoxia and treatment with a single injection of monocrotaline (60 mg/kg) was used to investigate the involvement of CXCR4 in PAH. Successful establishment of the PAH model was confirmed by significant differences… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Characterization and expression of senescence marker in prolonged passages of rat bone marrow-derived mesenchymal stem cells

N Ridzuan, A Al Abbar, WK Yip, M Maqbool, R Ramasamy
  • Stem Cells Int 2016:
  • 2016
VIEW 1 EXCERPT

A phase I trial of LY2510924, a CXCR4 peptide antagonist, in patients with advanced cancer.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2014
VIEW 1 EXCERPT