High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias

  title={High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias},
  author={A. Lasa and Elena Serrano and Maite Carricondo and Maria Jos{\'e} Carnicer and Salut Brunet and Isabel Badell and Jorge Sierra and Anna M Avent{\'i}n and Josep Nomdedeu},
  journal={Annals of Hematology},
CEACAM family members are a set of widely expressed proteins involved in several biological functions, including cell adhesion, migration, signal transduction, and the regulation of gene expression. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). To investigate the CEACAM… CONTINUE READING


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