High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins

@article{Mahn2018HighefficiencyOS,
  title={High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins},
  author={Mathias Mahn and Lihi Gibor and Pritish Patil and Katayun Cohen-Kashi Malina and Shir Oring and Y. Printz and Rivka Levy and I. Lampl and O. Yizhar},
  journal={Nature Communications},
  year={2018},
  volume={9}
}
Optogenetic silencing allows time-resolved functional interrogation of defined neuronal populations. However, the limitations of inhibitory optogenetic tools impose stringent constraints on experimental paradigms. The high light power requirement of light-driven ion pumps and their effects on intracellular ion homeostasis pose unique challenges, particularly in experiments that demand inhibition of a widespread neuronal population in vivo. Guillardia theta anion-conducting channelrhodopsins… Expand
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