High efficiency germ-line transformation of mosquitoes

@article{Lobo2006HighEG,
  title={High efficiency germ-line transformation of mosquitoes},
  author={Neil F. Lobo and John Randall Clayton and Malcolm J. Fraser and Fotis C. Kafatos and Frank H. Collins},
  journal={Nature Protocols},
  year={2006},
  volume={1},
  pages={1312-1317}
}
The ability to manipulate the mosquito genome through germ-line transformation provides us with a powerful tool for investigating gene structure and function. It is also a valuable method for the development of novel approaches to combating the spread of mosquito-vectored diseases. To date, germ-line transformation has been demonstrated in several mosquito species. Transgenes are introduced into pre-blastocyst mosquito embryos using microinjection techniques that take a few hours, and progeny… CONTINUE READING

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