High efficiency coupling of alpha-1 adrenergic receptors to inositol phospholipid metabolism revealed by denervation of rat vas deferens.

@article{Minneman1988HighEC,
  title={High efficiency coupling of alpha-1 adrenergic receptors to inositol phospholipid metabolism revealed by denervation of rat vas deferens.},
  author={Kenneth P. Minneman and Geoffrey K. Mumford and Peter W. Abel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={244 1},
  pages={226-30}
}
The effect of surgical denervation on alpha-1 adrenergic receptor-stimulated inositol phosphate (IP) formation was examined in rat vas deferens. Rings of tissue from acutely reserpinized animals were incubated with [3H]inositol in the presence of lithium to block IP degradation and desmethylimipramine to block neuronal uptake of norepinephrine. Eighteen days after denervation the potency of norepinephrine in stimulating [3H]IP accumulation was increased 10-fold. The potency of epinephrine was… CONTINUE READING