High drug loading and pH-responsive targeted nanocarriers from alginate-modified SPIONs for anti-tumor chemotherapy.

Abstract

To increase the accumulation of nanocarriers at the tumor site and reduce premature drug leakage, we fabricated alginate modified superparamagnetic iron oxide nanoparticles (SPIONs) with magnetic targeting capability for pH-responsive release of the anticancer drug doxorubicin (DOX) in tumor-cell microenvironments. The drug loading content (DLC) of SPION-4… (More)

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Cite this paper

@article{Peng2016HighDL, title={High drug loading and pH-responsive targeted nanocarriers from alginate-modified SPIONs for anti-tumor chemotherapy.}, author={Na Peng and Bo Wu and Lei Wang and Weiyang He and Ziye Ai and Xingjian Zhang and Yanfeng Wang and Lin Fan and Qifa Ye}, journal={Biomaterials science}, year={2016}, volume={4 12}, pages={1802-1813} }