High doses of 2,2′‐dithienyl diselenide cause systemic toxicity in rats: an in vitro and in vivo study

@article{Chagas2013HighDO,
  title={High doses of 2,2′‐dithienyl diselenide cause systemic toxicity in rats: an in vitro and in vivo study},
  author={P. M. Chagas and C. F. Bortolatto and E. A. Wilhelm and C. W. Nogueira},
  journal={Journal of Applied Toxicology},
  year={2013},
  volume={33}
}
Organoselenium compounds have important pharmacological properties. However, these compounds can cause toxicity, typically related to oxidation of endogenous thiols. The aim of this study was to investigate whether 2,2′‐dithienyl diselenide (DTDS) has potential toxicity in vitro and in vivo. Therefore, sulfhydryl‐containing enzyme activities, δ‐aminolevulinic acid dehydratase (δ‐ALA‐D) and Na+–K+‐ATPase were used to predict DTDS toxicity in rat brain homogenate in vitro. In in vivo experiments… Expand
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