High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity.

@article{Hidayat2006HighdoseVT,
  title={High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity.},
  author={Levita K. Hidayat and Donald I. Hsu and Ryan M Quist and Kimberly A. Shriner and Annie Wong-Beringer},
  journal={Archives of internal medicine},
  year={2006},
  volume={166 19},
  pages={2138-44}
}
BACKGROUND Vancomycin hydrochloride treatment failure for infections caused by susceptible methicillin-resistant Staphylococcus aureus (MRSA) strains with high minimum inhibitory concentration (MIC) has prompted recent guidelines to recommend a higher vancomycin target trough of 15 to 20 microg/mL. METHODS A prospective cohort study of adult patients infected with MRSA was performed to determine the distribution of vancomycin MIC and treatment outcomes with vancomycin doses targeting an… CONTINUE READING
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