High-dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5-year multicenter, randomized, controlled study.

  title={High-dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5-year multicenter, randomized, controlled study.},
  author={Rolf Olsson and Kirsten Muri Boberg and O S de Muckadell and Stefan C. Lindgren and Rolf Hultcrantz and Geir Folvik and Helge Bell and Magnhild Gangs{\o}y-Kristiansen and Jon Matre and Andreas Rydning and Ola Wikman and {\AA}ke Danielsson and Hanna Sandberg-Gertz{\'e}n and K A Ung and Anders S Eriksson and Lars L{\"o}{\"o}f and Hanne Prytz and Hanns-Ulrich Marschall and Ulrika Broomé},
  volume={129 5},
BACKGROUND & AIMS There is no medical treatment of proven benefit for primary sclerosing cholangitis. This study aimed at studying the effect of a higher dose of ursodeoxycholic acid than previously used on survival, symptoms, biochemistry, and quality of life in this disease. METHODS A randomized placebo-controlled study was performed in tertiary and secondary gastroenterology units. A total of 219 patients were randomized to 17 to 23 mg/kg body weight per day of ursodeoxycholic acid (n… 

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