High-dose treatment with vitamin A analogues and risk of fractures.

  title={High-dose treatment with vitamin A analogues and risk of fractures.},
  author={Peter Vestergaard and Lars Rejnmark and Leif Mosekilde},
  journal={Archives of dermatology},
  volume={146 5},
OBJECTIVE To study fracture risk associated with use of systemic vitamin A analogue (isotretinoin and acitretin) treatment. DESIGN Case-control study. SETTING Nationwide registry. PARTICIPANTS A total of 124 655 patients with fractures (cases) and 373 962 age- and sex-matched controls. Main Outcome Measure Incidence of fractures in patients with and without exposure to systemic vitamin A analogues. Confounder control was performed for social variables, contacts with hospitals and general… CONTINUE READING
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