High dose tranylcypromine therapy for refractory depression.

  title={High dose tranylcypromine therapy for refractory depression.},
  author={Jay D. Amsterdam and N J Berwish},
  volume={22 1},
A substantial number of depressed patients will experience a chronic, treatment-resistant affective disorder. Aggressive treatment of these patients with various drug combinations, unconventional antidepressants, or electroconvulsive therapy has met with only partial success. There remains a pressing need to identify more effective methods of utilizing "first-line" antidepressant agents to achieve a more rapid therapeutic action. To this end, we initiated a study using high doses of the MAO… CONTINUE READING