High-dose subchronic imipramine treatment: effects on anxiety-like (conflict) behavior in rats.

@article{Commissaris1994HighdoseSI,
  title={High-dose subchronic imipramine treatment: effects on anxiety-like (conflict) behavior in rats.},
  author={R L Commissaris and Tracy J Hill},
  journal={Anxiety},
  year={1994},
  volume={1 3},
  pages={109-13}
}
In the management of both anxiety and depression, agents such as imipramine (IMI) are noted for their 3-5 week delay to onset of clinical effect. A similar delay to onset has been reported for the anxiolytic-like (i.e., anticonflict) effect of chronic IMI treatment (2.5 mg/kg, BID for 5 weeks) in the Conditioned Suppression of Drinking (CSD) conflict paradigm; similar effects have been reported with other antidepressants and in other conflict procedures. In contrast, in the Forced Swim Test… CONTINUE READING
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