High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia.

@article{Meyers2003HighdoseSU,
  title={High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia.},
  author={R L Meyers and Linda S. Book and Molly A. O'Gorman and William Daniel Jackson and Richard E. Black and Dale G. Johnson and Michael E. Matlak},
  journal={Journal of pediatric surgery},
  year={2003},
  volume={38 3},
  pages={406-11}
}
BACKGROUND/PURPOSE Early reports suggest that the use of steroids after Kasai portoenterostomy may improve bile flow and outcome in infants with biliary atresia. METHODS Of 28 infants with biliary atresia, half received adjuvant high-dose steroids, and half received standard therapy. Infants in the steroid group (n = 14) received intravenous solumedrol (taper of 10, 8, 6, 5, 4, 3, 2 mg/kg/d), followed by 8 to 12 weeks of prednisone (2 mg/kg/d). The steroid protocol also included… CONTINUE READING

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