High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis.

@article{Fitzsimmons1997HighdosePS,
  title={High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis.},
  author={Stacey C. Fitzsimmons and G A Burkhart and Drucy S. Borowitz and Richard J. Grand and Thomas S Hammerstrom and Peter R. Durie and John D. Lloyd-Still and Albert B. Lowenfels},
  journal={The New England journal of medicine},
  year={1997},
  volume={336 18},
  pages={1283-9}
}
BACKGROUND Fibrosing colonopathy has been reported in young children with cystic fibrosis, the majority of whom take high-strength pancreatic-enzyme supplements to control intestinal malabsorption. We conducted a case-control study in the United States to investigate the relation between dose and type of pancreatic-enzyme supplement and fibrosing colonopathy. METHODS Children with histopathologically confirmed cases of fibrosing colonopathy who required colectomy for colonic strictures from… CONTINUE READING

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