High dose methylprednisolone therapy reduces expression of JE/MCP-1 mRNA and macrophage accumulation in the ischemic rat brain.

Abstract

The effects of glucocorticoid (GC) on ischemic brain remain to be investigated. Since GC modulates immunological system, it also may inhibit macrophage accumulation in the ischemic brain. The GC effect, if any, on macrophages in ischemic brain, may be mediated through modulation of JE/MCP-1 gene, a strong monocyte attractant, which is expressed in the rat… (More)

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Cite this paper

@article{Kim1995HighDM, title={High dose methylprednisolone therapy reduces expression of JE/MCP-1 mRNA and macrophage accumulation in the ischemic rat brain.}, author={J S Kim and Michael Chopp and S. C. Gautam}, journal={Journal of the neurological sciences}, year={1995}, volume={128 1}, pages={28-35} }