High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes.

BACKGROUND Apoptosis is supposed to contribute to the elimination of T cells from the inflamed central nervous system in the natural disease course of multiple sclerosis (MS). In the animal model experimental autoimmune encephalomyelitis, T-cell apoptosis can be induced by high-dose glucocorticoid (GC) administration. OBJECTIVE To study the effects of… CONTINUE READING