High-dose methylprednisolone suppresses experimental allergic neuritis in the Lewis rat.

@article{Watts1989HighdoseMS,
  title={High-dose methylprednisolone suppresses experimental allergic neuritis in the Lewis rat.},
  author={Peter M Watts and Wilson A. Taylor and Richard A. C. Hughes},
  journal={Experimental neurology},
  year={1989},
  volume={103 1},
  pages={101-4}
}
High dose methylprednisolone (50 mg kg-1, daily) was administered to Lewis rats with experimental allergic neuritis from onset of the disease. Disease severity was reduced and recovery was significantly more rapid than that in saline-injected controls. Histological examination showed reduction of endoneurial edema, cellular infiltration, and demyelination. The results provide experimental evidence supporting the trial of high dose steroids in human demyelinating polyradiculoneuropathy.