High dose methotrexate treatment in children with acute lymphoblastic leukaemia may be optimised by a weight-based dose calculation.

@article{Jnsson2011HighDM,
  title={High dose methotrexate treatment in children with acute lymphoblastic leukaemia may be optimised by a weight-based dose calculation.},
  author={Peter J{\"o}nsson and Tor Sk{\"a}rby and Jesper Heldrup and Henrik Daa Schr{\o}der and Peter H{\"o}glund},
  journal={Pediatric blood & cancer},
  year={2011},
  volume={57 1},
  pages={
          41-6
        }
}
BACKGROUND The inter-individual variation in exposure to methotrexate is considerable after intravenous high dose methotrexate (HDMTX) administration and both under- and over exposures may have dire consequences. Thus, optimal dose individualisation is of paramount importance. PROCEDURE We studied how pharmacokinetic parameters were related to outcome in 340 patients with acute lymphoblastic leukaemia (ALL). A population pharmacokinetic model was developed with data from 1284 HDMTX courses in… CONTINUE READING

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