High-dose methotrexate and HELP [Holoxan (ifosfamide), eldesine (vindesine), platinum]--doxorubicin in non-metastatic osteosarcoma of the extremity: a French multicentre pilot study. Fédération Nationale des Centres de Lutte contre le Cancer and Société Française d'Oncologie Pédiatrique.

@article{Philip1999HighdoseMA,
  title={High-dose methotrexate and HELP [Holoxan (ifosfamide), eldesine (vindesine), platinum]--doxorubicin in non-metastatic osteosarcoma of the extremity: a French multicentre pilot study. F{\'e}d{\'e}ration Nationale des Centres de Lutte contre le Cancer and Soci{\'e}t{\'e} Française d'Oncologie P{\'e}diatrique.},
  author={Thierry Philip and Cătălina Iliescu and M. C. Demaille and H{\'e}l{\`e}ne D Pacquement and Jean Claude Gentet and Ivan Krakowski and Patricia Soler-Michel and Philippe Thiesse and Franck Chauvin and Jean-Yves Blay and Maud Brunat-Mentigny},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1999},
  volume={10 9},
  pages={1065-71}
}
UNLABELLED This study evaluates histological response, long-term outcome, and toxicity in an intensive chemotherapy program given before surgery. PATIENTS AND METHODS Sixty-two patients (39 males, 23 females: median age 14) with biopsy, chest computerised-tomography, technetium bone-scan and magnetic resonance imaging, were enrolled. Primary localisations were femur (44%) and tibia (26%). Induction chemotherapy involved seven courses of high-dose methotrexate and two courses of HELP… CONTINUE READING

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