High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria.

  title={High-dose mefloquine in the treatment of multidrug-resistant falciparum malaria.},
  author={Feiko O Ter Kuile and François Henry Nosten and M Thieren and Christine Luxemburger and Michael D. Edstein and Tan Chongsuphajaisiddhi and Lucy Phaipun and H. Kyle Webster and Nicholas J White},
  journal={The Journal of infectious diseases},
  volume={166 6},
The therapeutic efficacy and toxicity of a high-dose (25 mg/kg) mefloquine regimen (M25) and the currently recommended regimen of 15 mg/kg (M15) were compared in 199 patients with acute falciparum malaria in an area with deteriorating multidrug resistance on the Thai-Burmese border. The clinical and parasitologic responses were significantly more rapid with M25. The incidence of treatment failures by day 7-9 was 7% for M15 and 1% for M25 (P = .03) and had increased to 40% and 9%, respectively… CONTINUE READING
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