High-dose ketoconazole therapy in patients with metastatic prostate cancer.

@article{Tapazoglou1986HighdoseKT,
  title={High-dose ketoconazole therapy in patients with metastatic prostate cancer.},
  author={E Tapazoglou and Marappa G. Subramanian and Muhyi al-Sarraf and Cynthia Kresge and David A. Decker},
  journal={American journal of clinical oncology},
  year={1986},
  volume={9 5},
  pages={
          369-75
        }
}
High-dose ketoconazole, 400 mg orally every 8 h, was administered in two groups of patients with metastatic prostate cancer. Group A consisted of 10 patients who had not undergone orchiectomy and Group B, eight patients who had orchiectomy prior to the study. Significant declines in testosterone, androstenedione, and dehydroepiandrosterone levels, reciprocal elevation of the gonadotropin levels (FSH and LH), and a persistent fall in serum acid phosphatase levels were observed in Group A… CONTINUE READING