High-dose irinotecan plus LV5FU2 or simplified LV5FU (HD-FOLFIRI) for patients with untreated metastatic colorectal cancer: a new way to allow resection of liver metastases?

@article{Ducreux2008HighdoseIP,
  title={High-dose irinotecan plus LV5FU2 or simplified LV5FU (HD-FOLFIRI) for patients with untreated metastatic colorectal cancer: a new way to allow resection of liver metastases?},
  author={Michel P Ducreux and J I Raoul and Pierre Marti and Yacine Merrouche and Jean-Marie Tigaud and Christine Rebischung and Val{\'e}rie Boige},
  journal={Oncology},
  year={2008},
  volume={74 1-2},
  pages={17-24}
}
UNLABELLED The antitumor efficacy of irinotecan may be dose dependent. This study aimed to determine the safety and efficacy of high-dose (HD) irinotecan combined with LV5FU2 or simplified LV5FU (LV5FUs) in first-line treatment of metastatic colorectal cancer. PATIENTS AND METHODS Patients with unresectable and measurable metastatic colorectal cancer, not pretreated for metastatic disease, were given irinotecan 260 mg/m(2) combined with LV5FU2 in the first 25 patients, then with LV5FUs (HD… CONTINUE READING
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Updated results of BICC - C study comparing first - line irinotecan / fluoropymidine combinations with or without celecoxib in mCRC : Updated efficacy data

  • C Fuchs, J Marshall, +7 authors J Barrueco
  • Proc Am Soc Clin Oncol
  • 2007

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