High-dose intravenous methylprednisolone therapy for patients with Diamond-Blackfan anemia refractory to conventional doses of prednisone.

@article{Bernini1995HighdoseIM,
  title={High-dose intravenous methylprednisolone therapy for patients with Diamond-Blackfan anemia refractory to conventional doses of prednisone.},
  author={J C Bernini and Juan Manuel Carrillo and George R. Buchanan},
  journal={The Journal of pediatrics},
  year={1995},
  volume={127 4},
  pages={654-9}
}
OBJECTIVES To assess the efficacy and toxicity of very high doses of glucocorticoids in patients with congenital pure red cell aplasia (Diamond-Blackfan anemia) who did not respond to standard doses of prednisone. STUDY DESIGNS We prospectively treated eight patients with transfusion-dependent Diamond-Blackfan anemia with high intravenous doses of methylprednisolone. All patients had previously not responded to one or more oral courses of prednisone in standard doses and were dependent on… CONTINUE READING