High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome

  title={High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome},
  author={Marc Lambert and David Launay and Eric Hachulla and Sandrine Morell-Dubois and Vincent Soland and Viviane Queyrel and François Fourrier and Pierre-yves Hatron},
  journal={Critical Care Medicine},
Objective:The objective of this study was to report the dramatic improvement of patients with systemic capillary leak syndrome obtained with high-dose intravenous immunoglobulins. Design:Systemic capillary leak syndrome is a rare and life-threatening disorder characterized by hypotension that can lead to shock, weight gain, hypoalbuminemia, and elevated hematocrit secondary to unexplained episodic capillary fluid extravasation into the interstitial space. Because its cause is unknown, systemic… 
Intravenous immunoglobulin in systemic capillary leak syndrome: a case report and review of literature
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Diagnosis of Systemic Capillary Leak Syndrome in a Young Child Treated with Intravenous Immunoglobulin in the Acute Phase.
IVIG should be considered as acute therapy in pediatric patients with refractory shock and a clinical course suggestive of SCLS, and it drastically reversed the acute capillary leak in a 2-year-old previously healthy male.
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Interleukin-2 (IL-2) has been reported to increase endothelial permeability, causing vascular leak syndrome, and IVIG may have a beneficial effect on capillary leak symptoms by posttranscriptional IL-2 suppression.
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An up-to-date, evidence-based review of the understanding of Idiopathic systemic capillary leak syndrome and its management in the light of currently available evidence is provided.


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[A case report of systemic capillary leak syndrome. Effective treatment with immunoadsorption and leukotriene antagonist].
One patient with frequent attacks of SCLS is described, that did not respond to any kind of treatment regimens over a period of nine years, and therapy with regular immunoadsorption of plasma proteins and a leukotriene receptor antagonist was attempted.
SYSTEMIC CAPILLARY LEAK SYNDROME AND MONOCLONAL IgG GAMMOPATHY: Studies in a Sixth Patient and a Review of the Literature
Treatment of the acute attacks with administration of intravenous fluids, did not maintain an adequate intravascular volume and may lead to fluid overload upon return of normal capillary integrity.
Systemic capillary leak syndrome with monoclonal IgG and complement alterations. A case report on an episodic syndrome.
The complement activation might be part of the pathogenesis of the increased macromolecular permeability in this syndrome.
An unusual evolution of the systemic capillary leak syndrome.
A 33-year-old black male, referred to the authors' department in 1981 for the following symptoms consistent with typical SCLS: several episodes of shock with generalized oedema; diffuse pain; and transient anuria, died after two treatment courses from cardiac and hepatic amyloidosis in April 2001.
Idiopathic capillary leak syndrome: evidence of CD8-positive lymphocytes surrounding damaged endothelial cells.
Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years.
An initial diagnosis of sepsis was made, but the lack of fever and absence of a demonstrable organism or source led to a revision of diagnosis to SLCS, and this article reviews these cases.
Intravenous immunoglobulin in autoimmune disorders: an insight into the immunoregulatory mechanisms.