High-dose intravenous immunoglobulin and serum viscosity: risk of precipitating thromboembolic events.

@article{Dalakas1994HighdoseII,
  title={High-dose intravenous immunoglobulin and serum viscosity: risk of precipitating thromboembolic events.},
  author={Marinos C. Dalakas},
  journal={Neurology},
  year={1994},
  volume={44 2},
  pages={223-6}
}
High-dose intravenous immunoglobulin (IVIg) can increase blood viscosity in vitro and has been associated with cardiovascular or cerebrovascular thromboembolism. Because thromboembolic events were observed in two (3%) of 65 patients we treated with IVIg, we measured serum viscosity serially in 13 patients (five with amyotrophic lateral sclerosis [ALS], eight with IgM paraproteinemic polyneuropathy) before and immediately after each of three consecutive monthly infusions of IVIg. We correlated… CONTINUE READING
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