High-dose immunoglobulin therapy for severe IgA nephropathy and Henoch-Schönlein purpura.

  title={High-dose immunoglobulin therapy for severe IgA nephropathy and Henoch-Sch{\"o}nlein purpura.},
  author={Gordon Rostoker and D Desvaux-Belghiti and Yannick Pilatte and M Petit-Phar and C A Philippon and Lionel Deforges and H Terzidis and Liliane Intrator and Charles Andre and Serge Adnot and Philippe Bonin and Philippe Bierling and Phillipe R{\'e}my and Gilbert Lagrue and Philippe Lang and B. Weil},
  journal={Annals of internal medicine},
  volume={120 6},
IgA nephropathy (IgAN) is characterized by IgA and C3 deposits in the mesangium [1] and is the most common form of primary glomerulonephritis [2]. Chronic renal failure occurs in approximately 25% of patients 10 years after diagnosis and in as many as 40% to 50% after 20 years [2-4]. Idiopathic Henoch-Schonlein purpura (HSP) is a more severe and systemic form of IgAN [4]. The causes of IgAN are still poorly understood. Glomerular damage might be related to deposits of IgA-containing immune… CONTINUE READING


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