High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity.

@article{Berrak2005HighdoseII,
  title={High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity.},
  author={Su G{\"u}ls{\"u}n Berrak and Margaret G Pearson and Semha Berberoğlu and Inci Erg{\"u}rhan Ilhan and Norman Jaffe},
  journal={Pediatric blood & cancer},
  year={2005},
  volume={44 3},
  pages={215-9}
}
BACKGROUND Sixteen pediatric osteosarcoma patients, previously treated with conventional chemotherapy (including ifosfamide (IFX), 9 g/m(2)) were retreated with high-dose ifosfamide (HD-IFX, 14 g/m(2) per course), following relapse or development of a new bone tumor. The objective was to obtain responses and an improved event-free survival (EFS). PROCEDURE HD-IFX was administered as described by Patel SR: J Clin Oncol 1997;15:2378. Efficacy of treatment was assessed initially after two to… CONTINUE READING

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