High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats.

@article{Antezana2003HighdoseIF,
  title={High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats.},
  author={David F. Antezana and Richard Clatterbuck and Nabil J. Alkayed and Stephanie J. Murphy and Lauren Anderson and James Anthony Frazier and Patricia D. Hurn and Richard J. Traystman and Ramon Joglar Tamargo},
  journal={Journal of neurosurgery},
  year={2003},
  volume={98 4},
  pages={
          860-6
        }
}
OBJECT Ibuprofen is an antiinflammatory drug that disrupts leukocyte-endothelial cell interactions by limiting expression of endothelial adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), also known as CD54. The authors hypothesized that ibuprofen could reduce the size of the infarct associated with transient focal ischemia by inhibition of ICAM-1 expression, and they evaluated its effects in rats treated with middle cerebral artery (MCA) occlusion. Ibuprofen treatment was… CONTINUE READING
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