High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells.

@article{Serafini2004HighdoseGC,
  title={High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells.},
  author={P. Serafini and Rebecca Carbley and Kimberly A. Noonan and Gladys Tan and Vincenzo Bronte and Ivan Borrello},
  journal={Cancer research},
  year={2004},
  volume={64 17},
  pages={6337-43}
}
Tumor vaccines have shown promise in early clinical trials. Among them, tumor cells genetically engineered to secrete biologically active granulocyte-macrophage colony-stimulating factor (GM-CSF) can generate a systemic antitumor immune response. Although the minimal required GM-CSF dose produced by modified tumor cells to achieve a measurable antitumor effect is well known, no data examined whether an upper therapeutic limit may exist for this vaccination strategy. Because recent data… CONTINUE READING
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