High-dose glucocorticoid treatment improves neurological recovery in head-injured mice.

@article{Hall1985HighdoseGT,
  title={High-dose glucocorticoid treatment improves neurological recovery in head-injured mice.},
  author={Edward D. Hall},
  journal={Journal of neurosurgery},
  year={1985},
  volume={62 6},
  pages={882-7}
}
The ability of a single large intravenous dose of the sodium succinate esters of the glucocorticoids methylprednisolone, prednisolone, or hydrocortisone to enhance early neurological recovery after moderate to severe blunt head injury was examined in male CF-1 mice. Unanesthetized mice were restrained and subjected to a 900 gm-cm head injury produced by a 50-gm weight dropped 18 cm. This injury resulted in immediate loss of consciousness (loss of the righting reflex) in all animals, and death… CONTINUE READING
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