High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP) clinical effects

Abstract

This study of the effect of high-dose intravenous gammaglobulins with one or two courses of therapy in 18 adults with idiopathic thrombocytopenia purpura showed a platelet rise in thirteen patients. The highest response rates were seen in splenectomized adults. In chronic patients the response was transient only. If therapy was effective, increased values of platelet-associated IgG were reduced, while shortened platelet survival times were prolonged. There was no influence of high-dose gammaglobulins on platelet function. Different 7S-preparations such as β-propiolactone modified Ig, pH 4 treated Ig and reduced and alkylated Ig have comparable effects.

DOI: 10.1007/BF00320713

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Cite this paper

@article{Schmidt1984HighDG, title={High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP) clinical effects}, author={R. E. Schmidt and Ulrich Budde and C. Br{\"{o}schen-Zywietz and Gwendolin Sch{\"a}fer and C. Mueller-Eckhardt}, journal={Blut}, year={1984}, volume={48}, pages={19-25} }