High dose folic acid supplementation of rats alters synaptic transmission and seizure susceptibility in offspring

@inproceedings{Girotto2013HighDF,
  title={High dose folic acid supplementation of rats alters synaptic transmission and seizure susceptibility in offspring},
  author={Fernando Girotto and Lucas O. M. Scott and Yosef Avchalumov and Jacqueline J. Harris and Stephanie Iannattone and Chris Drummond-Main and Rose Tobias and Luis E. Bello-Espinosa and Jong M. Rho and J{\"o}rn Davidsen and G. Campbell Teskey and Michael A. Colicos},
  booktitle={Scientific reports},
  year={2013}
}
Maternal folic acid supplementation is essential to reduce the risk of neural tube defects. We hypothesize that high levels of folic acid throughout gestation may produce neural networks more susceptible to seizure in offspring. We hence administered large doses of folic acid to rats before and during gestation and found their offspring had a 42% decrease… CONTINUE READING