High-dose fenretinide in oral leukoplakia.

  title={High-dose fenretinide in oral leukoplakia.},
  author={William N William and J Jack Lee and Scott Michael Lippman and Jack W Martin and Nitin Chakravarti and Hai T. Tran and Anita L. Sabichi and Edward S. Kim and Lei Feng and Reuben Lotan and Vassiliki A. Papadimitrakopoulou},
  journal={Cancer prevention research},
  volume={2 1},
We previously showed that low-dose fenretinide (200 mg/d) had limited activity in retinoid-resistant oral leukoplakia (34% response rate) possibly because serum drug levels were insufficient to induce retinoid receptor-independent apoptosis. Therefore, we designed the single-arm phase II trial reported here to investigate whether higher-dose fenretinide would improve leukoplakia response over that of our previous study. Leukoplakia patients received fenretinide (900 mg/m(2) twice daily) in four… CONTINUE READING
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