High dose factor VIIa improves clot structure and stability in a model of haemophilia B.

@article{Wolberg2005HighDF,
  title={High dose factor VIIa improves clot structure and stability in a model of haemophilia B.},
  author={Alisa S. Wolberg and Geoffrey A Allen and Dougald M Monroe and Ulla Hedner and Harold R. Roberts and M. Hoffman},
  journal={British journal of haematology},
  year={2005},
  volume={131 5},
  pages={645-55}
}
Factor IX (FIX) deficiency results in haemophilia B and high dose recombinant activated factor VII (rFVIIa) can decrease bleeding. Previously, we showed that FIX deficiency results in a reduced rate and peak of thrombin generation. We have now used plasma and an in vitro coagulation model to examine the effect of these changes in thrombin generation on fibrin clot structure and stability. Low FIX delayed the clot formation onset and reduced the fibrin polymerisation rate. Clots formed without… CONTINUE READING
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